Intersubject variation in replicated BE study [General Sta­tis­tics]

posted by atish_azad – 2008-04-01 08:15 (6098 d 05:28 ago) – Posting: # 1734
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Dear d_labes/all,

subject-by-formulation interaction variance is
sig_D^2=FA(1,1)^2+FA(2,1)^2-2*FA(1,1)*FA(2,1)

As far as WinNonlin is concerned Under 'Final Variance Parameters' values of lambda(1,1)_11, lambda(1,2)_11 and lambda(2,2)_11 corresponds to SAS output of FA(1,1), FA(2,1) and FA(2,2) respectively.

Based on above mentioned parameters we can calculate inter and intra subject variation.

Regards,

Atish

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