Bioequivalence and Bioavailability Forum

Intersubject variation in replicated BE study [General Statistics]

posted by atish_azad – 2008-04-01 08:15 (5723 d 07:59 ago) – Posting: # 1734
Views: 10,754

Dear d_labes/all,

subject-by-formulation interaction variance is
sig_D^2=FA(1,1)^2+FA(2,1)^2-2*FA(1,1)*FA(2,1)

As far as WinNonlin is concerned Under 'Final Variance Parameters' values of lambda(1,1)_11, lambda(1,2)_11 and lambda(2,2)_11 corresponds to SAS output of FA(1,1), FA(2,1) and FA(2,2) respectively.

Based on above mentioned parameters we can calculate inter and intra subject variation.

Regards,

Atish

Complete thread:

Intersubject variation in replicated BE study atish_azad 2008-03-20 11:33
- Intersubject variation in replicated BE study d_labes 2008-03-26 13:34
  - Intersubject variation in replicated BE study atish_azad 2008-03-31 15:02
    - Intersubject variation in replicated BE study Jaime_R 2008-03-31 15:09
      - Intersubject variation in replicated BE studyatish_azad 2008-04-01 06:15
    - Intersubject variation in replicated BE study d_labes 2008-04-01 10:01
      - Intersubject variation in replicated BE study atish_azad 2008-04-02 15:27

Intersubject variation in replicated BE study [General Sta­tis­tics]

Complete thread:

Intersubject variation in replicated BE study [General Statistics]