be careful with mixed models [Regulatives / Guidelines]

posted by mittyri – Russia, 2017-05-02 19:53 (2218 d 00:32 ago) – Posting: # 17293
Views: 29,297

Hi Artem,

Welcome to the world of mixed modeling!
Helmut suggested (see endnote c) to switch to the model with all effects as fixed. Your model is the same as suggested by FDA (with Subject as random). So Phoenix switched to the mixed model and used Satterthwaite degrees of freedom (which could be not integer).
Note that it is impossible to provide ANOVA tables (partial/sequential ss output PHX-speaking) for mixed models.

So due to no convention in Russian brains you are free to use your current model or the model provided by Helmut (with all effects fixed). Latter is more suitable for me due to hazelnut brain.

PS: are there any incomplete data (missed period) for some subjects?

Kind regards,

Complete thread:

UA Flag
 Admin contact
22,616 posts in 4,740 threads, 1,610 registered users;
14 visitors (0 registered, 14 guests [including 8 identified bots]).
Forum time: 20:26 CEST (Europe/Vienna)

Do not worry about your difficulties in mathematics.
I can assure you mine are still greater.    Albert Einstein

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz