Example [Regulatives / Guidelines]
Hi ElMaestro,
Yep. Below an example of model 1 in Phoenix/WinNonlin. Two groups (n=24 each), all effects fixed.
N: ΣnG = 48
G: 2
Numerator DF: G – 1 = 1
Denominator DF: N - 2G = 44
F: 0.0131109/0.0126246 = 1.0385149
❝ Could you tell how you got your F-test denominator? I am sure you are right, but I don't know where it came from. For an interaction of a between- and within-factor I think the rule of thumb (which is also a wee bit hard to define ) is to test against the within, which in this case would be the model residual.
Yep. Below an example of model 1 in Phoenix/WinNonlin. Two groups (n=24 each), all effects fixed.
Partial Sum of Squares
Hypothesis DF SS MS F_stat P_value
---------------------------------------------------------------
Group 1 0.0131109 0.0131109 1.0385149 0.31374
Sequence 1 0.0058638 0.0058638 0.4644731 0.49914
Treatment 1 0.0011965 0.0011965 0.0947752 0.75964
Group*Sequence 1 0.0108734 0.0108734 0.8612869 0.35844
Group*Period 2 0.0160976 0.0080488 0.6375490 0.53340
Group*Treatment 1 0.0131109 0.0131109 1.0385149 0.31374
Group*Sequence*Subject 44 0.555484 0.0126246 1 0.50000
Error 44 0.555484 0.0126246
Partial Tests of Model Effects
Hypothesis Numer_DF Denom_DF F_stat P_value
----------------------------------------------------------
Group 1 44 1.0385149 0.31374
Sequence 1 44 0.4644731 0.49914
Treatment 1 44 0.0947752 0.75964
Group*Sequence 1 44 0.8612869 0.35844
Group*Period 2 44 0.6375490 0.53340
Group*Treatment 1 44 1.0385149 0.31374
Group*Sequence*Subject 44 44 1 0.50000
N: ΣnG = 48
G: 2
Numerator DF: G – 1 = 1
Denominator DF: N - 2G = 44
F: 0.0131109/0.0126246 = 1.0385149
round(pf(1.0385149, 1, 44, lower.tail=FALSE), 5)
# [1] 0.31374
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
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- Low power of Group-by-Treatment interaction mittyri 2017-04-29 22:57
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- Let’s forget the Group-by-Treatment interaction, please! ElMaestro 2017-05-01 16:19
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- Some answers ElMaestro 2017-05-02 09:04
- ExampleHelmut 2017-05-02 12:35
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- Simulations Helmut 2017-05-05 14:38
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- loosing specificity due to low sensitivity Helmut 2017-05-09 00:55
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- Some answers Helmut 2017-05-02 01:10
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