## TIE depends on CVwR (and n) [RSABE / ABEL]

Hi Yura,

» Adjusted alpha is used to construct confidence intervals of the pharmacokinetic parameters for the index T-P?

What do you mean by “the index T-P”? For the EMA use the ‘Method A’ or ‘Method B’ as given in the Q&A-document. But instead of using the nominal α of 0.05 (i.e., the 100(1–2α) = 90% CI) apply the respective adjusted α. If the TIE would be inflated with α 0.05, the adjusted CI is always wider (i.e., conservative).

Dif-tor heh smusma 🖖
Helmut Schütz

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