TIE depends on CVwR (and n) [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2017-04-26 18:00 (1886 d 10:19 ago) – Posting: # 17270
Views: 10,362

Hi Yura,

» Adjusted alpha is used to construct confidence intervals of the pharmacokinetic parameters for the index T-P?

What do you mean by “the index T-P”? For the EMA use the ‘Method A’ or ‘Method B’ as given in the Q&A-document. But instead of using the nominal α of 0.05 (i.e., the 100(1–2α) = 90% CI) apply the respective adjusted α. If the TIE would be inflated with α 0.05, the adjusted CI is always wider (i.e., conservative).

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,167 posts in 4,645 threads, 1,572 registered users;
online 2 (0 registered, 2 guests [including 2 identified bots]).
Forum time: Sunday 04:19 CEST (Europe/Vienna)

The person interested in success has to learn
to view failure as a healthy, inevitable part
of the process of getting to the top.    Joyce Brothers

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5