Data for 2nd stage of Potvin’s designs [Two-Stage / GS Designs]

posted by BE-proff – Russia, 2017-02-18 06:40 (1240 d 07:10 ago) – Posting: # 17078
Views: 11,370

Hi All,

I have some questions on Potvin's designs:;-)

1) is it correct that GMR and CV are required for sample size calculation for 2nd stage in all Potvin's designs?

2) Why Method C is considered "better" for sponsors than Method B?

The 1st question arised because Potvin's article dated 2007 says that only CV is needed for A and B while Method C uses both GMR and CV.

But on the other hand there are also opinions that all methods require GMR and CV.

Unclear....:confused:

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