Bioequivalence and Bioavailability Forum • Scaling of Cmin

Scaling of Cmin [Regulatives / Guidelines]

posted by VStus – Poland, 2017-02-06 09:55 (3055 d 11:55 ago) – Posting: # 17017
Views: 12,402

Dear zizou,

No change in residual variance if I remove 'period' from the model.


anovadata <- lm(log(AUC) ~ prd + seq + rep + subj:seq, data=data, na.action=na.exclude)

anova(anovadata)



## Analysis of Variance Table

## 

## Response: log(AUC)

##           Df  Sum Sq  Mean Sq F value  Pr(>F)  

## prd        1 0.20989 0.209885  6.5803 0.01894 *

## rep        1 0.00507 0.005067  0.1589 0.69466  

## seq:subj  18 1.55131 0.086184  2.7020 0.01873 *

## Residuals 19 0.60602 0.031896                  

## ---

## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1



MSE       <- anova(anovadata)["Residuals","Mean Sq"]
100*sqrt(exp(MSE)-1)



## [1] 18.00281



anovadata <- lm(log(AUC) ~ seq + rep + subj:seq, data=data, na.action=na.exclude)

anova(anovadata)

## Analysis of Variance Table

## 

## Response: log(AUC)

##           Df  Sum Sq  Mean Sq F value  Pr(>F)  

## seq        1 0.20989 0.209885  6.5803 0.01894 *

## rep        1 0.00507 0.005067  0.1589 0.69466  

## seq:subj  18 1.55131 0.086184  2.7020 0.01873 *

## Residuals 19 0.60602 0.031896                  

## ---

## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Maybe MIXED procedure should be used?

Regards, VStus

Complete thread:

Type of study in modified release formulation EMEA Compliance 2014-03-13 09:43 [Regulatives / Guidelines]
- Type of study in modified release formulation EMEA nobody 2014-03-13 09:52
- Type of study in modified release formulation EMEA fno 2014-03-13 11:16
  - Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 11:02
    - Type of study in modified release formulation EMEA nobody 2014-11-27 11:37
      - Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 12:53
        
        Scaling of Cmin Helmut 2014-11-27 13:47
        
        Scaling of Cmin kumarnaidu 2014-11-27 15:12
        Scaling of Cmin kumarnaidu 2014-12-05 06:03
        
        Steady state kumarnaidu 2014-12-10 11:15
        
        Steady state nobody 2014-12-10 17:04
        
        Scaling of Cmin Dr_Dan 2014-12-10 17:21
        
        Scaling of Cmin Helmut 2014-12-10 18:40
        
        Scaling of Cmin d_labes 2014-12-11 13:09
        
        Scaling of Cmin Helmut 2014-12-11 14:53
        
        Scaling of Cmin VStus 2017-02-03 13:04
        
        Scaling of Cmin zizou 2017-02-03 13:49
        
        Scaling of Cmin VStus 2017-02-03 15:37
        Scaling of CminVStus 2017-02-06 08:55