Scaling of Cmin [Regulatives / Guidelines]
Dear zizou,
Thank you very much for the feedback!
I've tried 4 periods instead of 2 and got even higher variation, which seems to be an overestimation:
Removing replication from the model does not change residual MS :)
Regards, VStus
Thank you very much for the feedback!
I've tried 4 periods instead of 2 and got even higher variation, which seems to be an overestimation:
summary(data)
## subj seq prd drug rep AUC
## 1 : 2 RT:20 1:10 R:40 R1:20 Min. : 439.0
## 2 : 2 TR:20 2:10 R2:20 1st Qu.: 656.5
## 3 : 2 3:10 Median : 781.5
## 4 : 2 4:10 Mean : 795.6
## 5 : 2 3rd Qu.: 929.8
## 6 : 2 Max. :1297.0
## (Other):28
anovadata <- lm(log(AUC) ~ seq + subj:seq + rep + prd, data=data, na.action=na.exclude)
anova(anovadata)
## Analysis of Variance Table
##
## Response: log(AUC)
## Df Sum Sq Mean Sq F value Pr(>F)
## seq 1 0.20989 0.209885 6.2514 0.02230 *
## rep 1 0.00507 0.005067 0.1509 0.70222
## prd 1 0.00169 0.001689 0.0503 0.82505
## seq:subj 18 1.55131 0.086184 2.5670 0.02631 *
## Residuals 18 0.60433 0.033574
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
100*sqrt(exp(0.033574)-1)
## [1] 18.47812
Removing replication from the model does not change residual MS :)
Regards, VStus
Complete thread:
- Type of study in modified release formulation EMEA Compliance 2014-03-13 09:43 [Regulatives / Guidelines]
- Type of study in modified release formulation EMEA nobody 2014-03-13 09:52
- Type of study in modified release formulation EMEA fno 2014-03-13 11:16
- Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 11:02
- Type of study in modified release formulation EMEA nobody 2014-11-27 11:37
- Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 12:53
- Scaling of Cmin Helmut 2014-11-27 13:47
- Scaling of Cmin kumarnaidu 2014-11-27 15:12
- Scaling of Cmin kumarnaidu 2014-12-05 06:03
- Steady state kumarnaidu 2014-12-10 11:15
- Steady state nobody 2014-12-10 17:04
- Scaling of Cmin Dr_Dan 2014-12-10 17:21
- Scaling of Cmin Helmut 2014-12-10 18:40
- Scaling of Cmin d_labes 2014-12-11 13:09
- Scaling of Cmin Helmut 2014-12-11 14:53
- Scaling of Cmin VStus 2017-02-03 13:04
- Scaling of Cmin zizou 2017-02-03 13:49
- Scaling of CminVStus 2017-02-03 15:37
- Scaling of Cmin VStus 2017-02-06 08:55
- Scaling of Cmin zizou 2017-02-03 13:49
- Scaling of Cmin VStus 2017-02-03 13:04
- Scaling of Cmin Helmut 2014-12-11 14:53
- Scaling of Cmin d_labes 2014-12-11 13:09
- Scaling of Cmin Helmut 2014-12-10 18:40
- Steady state kumarnaidu 2014-12-10 11:15
- Scaling of Cmin Helmut 2014-11-27 13:47
- Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 12:53
- Type of study in modified release formulation EMEA nobody 2014-11-27 11:37
- Type of study in modified release formulation EMEA kumarnaidu 2014-11-27 11:02