Lexical order [Software]
Hi Sundar,
Both software packages by default give the LSM difference in lexical order. If you coded test with T and reference with R, the difference will be given as R – T (since R < T).
It might be that your SAS-code changed the order by a statement similar to this one:
My method to recode the LSM differences (which works for any specification of T and R):
Rename to
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❝ Could you please clarify the reason for getting results of LSM differences and confidence limit values in opposite to one another (eg., negative vs positive or positive vs negative values) when you evaluate the same data using SAS and Phoenix WinNonlin.
Both software packages by default give the LSM difference in lexical order. If you coded test with T and reference with R, the difference will be given as R – T (since R < T).
It might be that your SAS-code changed the order by a statement similar to this one:
lsmeans formulation / pdiff=control("R") CL alpha=0.10;
Bioequivalence > Output Data > LSM Differences
.My method to recode the LSM differences (which works for any specification of T and R):
LSM Differences > Send To > Data > Data Wizard
Rename to
Reordered LSM Differences
and add these Custom Transformations
:- R:
left(Level_Level, search(Level_Level, '-', 1)-2)
- T:
right(Level_Level, search(Level_Level, '-', 1)-2)
- Relevel:
concatenate(T, ' - ', R)
- Difference:
-Estimate
- Lower:
-Upper_CI
- Upper:
-Lower_CI
Filter: Exclude
⦿ Level_Level
⦿ Estimate
⦿ Lower_CI
⦿ Upper_CI
⦿ R
⦿ T
Properties
Relevel => Level_level
Difference => Estimate
Lower => Lower_CI
Upper => Upper_CI
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Complete thread:
- LSM differences in SAS vs Phoenix msmnainar 2017-01-20 07:49 [Software]
- LSM differences in SAS vs Phoenix Shuanghe 2017-01-20 12:31
- Lexical orderHelmut 2017-01-20 13:34
- Lexical order ElMaestro 2017-01-20 20:12