Winnonlin AUMC_TAU and others [Software]
Hi Helmut and all,
the formula for MRTINF (using Cpred version) is the following:
AUMC_TAU is a'cut-off' version like AUC_TAU.
BTW AUMC is calculated inside modeling like that:
So the modeling version is AUMC extrapolated to infinity. If you remove Tau from the Dosing sheet in NCA object, you'll see AUMCINF_pred which is close enough to the AUMC value in PK model
❝ BTW, it is one of the mysteries of Phoenix/WinNonlin why the NCA’s MRT is correct though the AUMC isn’t. My pocket calculator gives 294.97/257.15=1.1471.
the formula for MRTINF (using Cpred version) is the following:
MRTINF_pred = ![[image]](img/uploaded/image170.jpg)
AUMC_TAU is a'cut-off' version like AUC_TAU.
BTW AUMC is calculated inside modeling like that:
AUMC = A1InfDose/(tvV*Ke*Ke) + (Tinf*A1InfDose/(2*tvV*Ke)
So the modeling version is AUMC extrapolated to infinity. If you remove Tau from the Dosing sheet in NCA object, you'll see AUMCINF_pred which is close enough to the AUMC value in PK model
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- WinNonlin: NCA of multiple dosing plasma PK profile bobmarlo 2017-01-15 17:22 [Software]
- WinNonlin: steady state setup Helmut 2017-01-16 13:15
- WinNonlin: steady state setup BE-proff 2017-01-17 07:54
- Accumulation Helmut 2017-01-18 02:22
- WinNonlin: steady state setup bobmarlo 2017-01-17 20:36
- NCA agrees with PK-modeling Helmut 2017-01-18 01:41
- NCA agrees with PK-modeling bobmarlo 2017-01-18 05:06
- Winnonlin AUMC_TAU and othersmittyri 2017-01-18 18:00
- NCA agrees with PK-modeling Helmut 2017-01-18 01:41
- WinNonlin: steady state setup BE-proff 2017-01-17 07:54
- WinNonlin: NCA of multiple dosing plasma PK profile mittyri 2017-01-16 17:29
- WinNonlin: steady state setup Helmut 2017-01-16 13:15