Winnonlin AUMC_TAU and others [Software]

posted by mittyri – Russia, 2017-01-18 19:00 (2947 d 11:15 ago) – Posting: # 16975
Views: 11,817

(edited on 2017-01-18 20:20)

Hi Helmut and all,

❝ BTW, it is one of the mysteries of Phoenix/WinNonlin why the NCA’s MRT is correct though the AUMC isn’t. My pocket calculator gives 294.97/257.15=1.1471.


the formula for MRTINF (using Cpred version) is the following:

MRTINF_pred = [image]

AUMC_TAU is a'cut-off' version like AUC_TAU.
BTW AUMC is calculated inside modeling like that:

AUMC = A1InfDose/(tvV*Ke*Ke) + (Tinf*A1InfDose/(2*tvV*Ke)

So the modeling version is AUMC extrapolated to infinity. If you remove Tau from the Dosing sheet in NCA object, you'll see AUMCINF_pred which is close enough to the AUMC value in PK model

Kind regards,
Mittyri

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