Bioequivalence and Bioavailability Forum • Paired vs. crossover

Paired vs. crossover [Software]

posted by DavidManteigas – Portugal, 2017-01-17 16:35 (3431 d 05:52 ago) – Posting: # 16967
Views: 12,054

@Maryam

For a 2x2 cross-over, the following code will get you everything you need (ods outputs LSMeandiffCL, LSMeans, AltErrTests and OverallANOVA)

proc glm data=replicate;

class formulation subject period sequence;

model logDATA= sequence subject (sequence) period formulation;

estimate "test-ref" formulation -1+1;

test h=sequence e=subject(sequence);

lsmeans formulation / adjust=t pdiff=control("R") CL alpha=0.10;

run;

Formulation and Period p values come from OverallAnova, while sequence p value from AltErrTests.

This code in principle will fit both EMA and FDA requirements for a 2x2 design. Although FDA requests subject within sequence as random effect, this will not change the result.

Complete thread:

SAS Maryam 2017-01-13 16:28 [Software]
- SAS Mahmoud 2017-01-15 08:56
  - Paired vs. crossover Helmut 2017-01-15 12:16
    - Paired vs. crossover Maryam 2017-01-15 16:44
      - Paired vs. crossoverDavidManteigas 2017-01-17 15:35
        
        Picky Helmut 2017-01-18 12:57
        
        Picky DavidManteigas 2017-01-27 15:03
  - SAS Maryam 2017-01-15 16:31
- SAS Mahmoud 2017-01-15 14:36
  - SAS Maryam 2017-01-15 16:50
- SAS Mahmoud 2017-01-16 10:08