Bioequivalence and Bioavailability Forum

Paired vs. crossover [Software]

posted by Helmut  – Vienna, Austria, 2017-01-15 13:16 (3435 d 01:57 ago) – Posting: # 16948
Views: 12,376

Salam Mahmoud,

❝ Dear Sir

I assume that Maryam is not a Sir.

❝ For BE studies do not use the t-test paired data.

We don’t know the design of Maryam’s study. What if it was not a crossover? Examples where a paired t-test would be correct indeed:

• Assessment of linear PK. Single dose followed by steady state and AUC_0–τ vs. AUC_0–∞.
  
• 4-period food-effect design where periods 1&2 fed and periods 3&4 fasting. Crossover in fed and fasting state but assessment of the food effect of T and R by a paired t-test (assuming no period effects).

@Maryam: What is the structure of you data? I don’t speak SAS but which error did you get?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• SAS Maryam 2017-01-13 16:28 [Software] 
  • SAS Mahmoud 2017-01-15 08:56
    • Paired vs. crossoverHelmut 2017-01-15 12:16
      • Paired vs. crossover Maryam 2017-01-15 16:44
        • Paired vs. crossover DavidManteigas 2017-01-17 15:35
          • Picky Helmut 2017-01-18 12:57
            • Picky DavidManteigas 2017-01-27 15:03
    • SAS Maryam 2017-01-15 16:31
  • SAS Mahmoud 2017-01-15 14:36
    • SAS Maryam 2017-01-15 16:50
  • SAS Mahmoud 2017-01-16 10:08