Using f2 for compounds that never reach 85% dissolution [Dissolution / BCS / IVIVC]

posted by nobody – 2017-01-03 20:19 (2960 d 01:17 ago) – Posting: # 16924
Views: 6,282

Hi!

As the experts are apparently still on holiday :-) I might start with some questions/remarks.

Liposomes with doxorubicin (just wild guessing here ;-) ) are no oral formulation afaik. Why would you do dissolution testing (simulation GI tract, normally)?

The fraction of dose you get into solution pretty much depends on the media you use for your testing, in my opinion.

So maybe some more details on the kind of products/projects your on might be helpful to get more response. :-)

Kindest regards, nobody

Complete thread:

UA Flag
Activity
 Admin contact
23,379 posts in 4,913 threads, 1,661 registered users;
124 visitors (0 registered, 124 guests [including 13 identified bots]).
Forum time: 21:36 CET (Europe/Vienna)

Science is what you know.
Philosophy is what you don’t know.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5