Bioequivalence and Bioavailability Forum • Using f2 for compounds that never reach 85% dissolution

Using f2 for compounds that never reach 85% dissolution [Dissolution / BCS / IVIVC]

posted by nobody – 2017-01-03 20:19 (3107 d 07:14 ago) – Posting: # 16924
Views: 6,663

Hi!

As the experts are apparently still on holiday :-)

I might start with some questions/remarks.

Liposomes with doxorubicin (just wild guessing here ;-)

) are no oral formulation afaik. Why would you do dissolution testing (simulation GI tract, normally)?

The fraction of dose you get into solution pretty much depends on the media you use for your testing, in my opinion.

So maybe some more details on the kind of products/projects your on might be helpful to get more response. :-)

—
Kindest regards, nobody

Complete thread:

Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-03 15:48 [Dissolution / BCS / IVIVC]
- Using f2 for compounds that never reach 85% dissolutionnobody 2017-01-03 19:19
  - Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-04 10:46
    - Using f2 for compounds that never reach 85% dissolution nobody 2017-01-04 11:52
- Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-16 17:27
  - Using f2 for compounds that never reach 85% dissolution Dr_Dan 2017-01-16 18:10
    - Using f2 for compounds that never reach 85% dissolution wligtenberg 2017-01-17 09:00