## Impact of minimum stage 2 sample size on the TIE: example [Two-Stage / GS Designs]

Hi Helmut,

I am still lost, I must confess. Perhaps it is because I am not using the power2Stage package at all.

» I’ll give two examples. Both at the location (n1 12, CV 20%) of the maximum TIE.
» Simulating for power (at 0.95):
1. No lower limit of n2
» library(Power2Stage)
» power.2stage(method="B", alpha=rep(0.0294, 2), CV=0.2,
»              n1=12, GMR=0.95, targetpower=0.8, min.n2=0)

Should this not be min.n2=2 ? Or is it the "same difference"??

Do you think you have it in your heart to explain in slow motion to a dimwit like me who read your posts quite a few times which point you are trying to prove or investigating?

Otherwise I am afraid I will need to question you next time we meet f2f. And that might not be in the distant future

I could be wrong, but...

Best regards,
ElMaestro

"Pass or fail" (D. Potvin et al., 2008)