Bioequivalence and Bioavailability Forum • AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone

AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone [PK / PD]

posted by luvblooms – India, 2016-12-28 09:05 (3009 d 07:05 ago) – Posting: # 16891
Views: 5,676

Hi Anky

❝

❝ Can anyone suggest which antiemetic shall be used to mitigate undesirable effect of Carbidopa, Levodopa and Entacapone tablets like nausea, vomiting in Bioequivalence study in normal human subjects?

Not for the said combination but yes, many companies have used antiemetic drugs to counteract the nausea and vomiting observed with certain anticholinesterases.

Details available at A Randomized, Crossover, Single-Dose Bioequivalence Study of Two Extended-Release Tablets of Donepezil 23 mg in Healthy Human Volunteers under Fasting and Fed States

And product was approved by USFDA

❝ Please share antiemetic drug with reference.

My suggestion, write to FDA before starting any study if you are doubtful.

—
~A happy Soul~

Complete thread:

AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 14:50 [PK / PD]
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
  - AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
    - Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
      - Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
        
        Antiemetic Drugs can change PK profiles mittyri 2016-12-27 19:33
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacaponeluvblooms 2016-12-28 08:05