Bioequivalence and Bioavailability Forum • Antiemetic Drugs can change PK profiles

Antiemetic Drugs can change PK profiles [PK / PD]

posted by anky1212 – India, 2016-12-27 19:02 (3009 d 22:16 ago) – Posting: # 16888
Views: 5,672

Thanks mittyri for your reply.

Since domperidone increases bioavailability, we may not use it for BE of LCE. Also, drugs which is dopamine antagonist may worsen pd symptoms and may not be used as antiemetic for BE OF LCE.

Can we use ondansetron for BE of LCE to mitigate emesis, nausea?

But i need reference for the same which i couldn't fimd.

Please reply if anyone finds reference or any useful suggestion.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 14:50 [PK / PD]
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
  - AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
    - Antiemetic Drugs can change PK profiles mittyri 2016-12-27 17:15
      - Antiemetic Drugs can change PK profilesanky1212 2016-12-27 18:02
        
        Antiemetic Drugs can change PK profiles mittyri 2016-12-27 19:33
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone luvblooms 2016-12-28 08:05