Antiemetic Drugs can change PK profiles [PK / PD]
Dear anky1212,
This question is not so easy to answer.
The best way to control vomiting and nausea is peripheral dopamine receptor blocker like Domperidone or central blocker like Metoclopramide (also blocks central effects, but they aren't needed here, right?).
By the way using these drugs you can change gastric/enteric motility and also bioavailability of drugs of interest.
Please consider to review this paper
I didn't find any data regarding active antiemetic therapy in BEQ studies for Stalevo.
Maybe more experienced colleagues have more information...
This question is not so easy to answer.
The best way to control vomiting and nausea is peripheral dopamine receptor blocker like Domperidone or central blocker like Metoclopramide (also blocks central effects, but they aren't needed here, right?).
By the way using these drugs you can change gastric/enteric motility and also bioavailability of drugs of interest.
Please consider to review this paper
I didn't find any data regarding active antiemetic therapy in BEQ studies for Stalevo.
Maybe more experienced colleagues have more information...
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 14:50 [PK / PD]
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- Antiemetic Drugs can change PK profilesmittyri 2016-12-27 17:15
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profiles mittyri 2016-12-27 19:33
- Antiemetic Drugs can change PK profiles anky1212 2016-12-27 18:02
- Antiemetic Drugs can change PK profilesmittyri 2016-12-27 17:15
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone anky1212 2016-12-27 15:43
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone luvblooms 2016-12-28 08:05
- AntiemeticDrug selection for BE study of Carbidopa, Levodopa and Entacapone BE-proff 2016-12-27 15:08