CI and alfa [RSABE / ABEL]

posted by ElMaestro  – Denmark, 2016-11-24 22:35 (2997 d 19:19 ago) – Posting: # 16810
Views: 4,658

Hello Yura,

❝ We spend in replicate design TRR / RTR / RRT three repeated measurements. Question: how to take the level of alpha and confidence interval for the point estimate calculation between measurements (T-R1, T-R2, R1-R2)? I assumed an alpha of 0.017 and CI 96.6. :confused:


Something sounds a bit odd here. TRR/RTR/RRT with two different Ref's is not a replicate design; alpha adjustment is in that situation usually not what you want to do. But I would be entirely wrong, depending on the question you are actually asking in your trial. What is the purpose of the R1-R2 CI?

Let's get some more info. :-)

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,376 posts in 4,912 threads, 1,667 registered users;
235 visitors (0 registered, 235 guests [including 17 identified bots]).
Forum time: 17:55 CET (Europe/Vienna)

The great tragedy of Science – the slaying
of a beautiful hypothesis by an ugly fact.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5