PROC GLM fixes Subject [🇷 for BE/BA]
Dear Mittyri and all,
Its a 2x2 crossover study.
proc glm data=replicate;
class formulation subject period sequence;
model logDATA= sequence subject (sequence) period formulation;
estimate "test-ref" formulation -1+1;
test h=sequence e=subject(sequence);
lsmeans formulation / adjust=t pdiff=control("R") CL alpha=0.10;
run;
This is Method A from EMA Q&A guidance. Ideally in GLM all effects are fixed.
Can we call here sub(seq) as a fixed effect?
❝ Are you working with Replicate study? The things are different there
Its a 2x2 crossover study.
❝ I think you can provide the SAS code above, so all experts will understand that all effects are still fixed, and the reason of random part there is just an F test.
proc glm data=replicate;
class formulation subject period sequence;
model logDATA= sequence subject (sequence) period formulation;
estimate "test-ref" formulation -1+1;
test h=sequence e=subject(sequence);
lsmeans formulation / adjust=t pdiff=control("R") CL alpha=0.10;
run;
This is Method A from EMA Q&A guidance. Ideally in GLM all effects are fixed.
Can we call here sub(seq) as a fixed effect?
—
Kumar Naidu
Kumar Naidu
Complete thread:
- R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 00:13 [🇷 for BE/BA]
- R code for analyzing classical 2X2 crossover designed bioequivalence data ElMaestro 2016-01-22 00:59
- R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 01:26
- On random effects and bogus statements ElMaestro 2016-01-22 12:13
- FDA 'own' SAS code for 2x2 d_labes 2016-01-27 09:57
- FDA 'own' SAS code for 2x2 nobody 2016-01-27 10:09
- OT: PM to ElMaestro Helmut 2016-01-27 13:39
- On coffee and such... ElMaestro 2016-01-27 13:47
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- Geometric means ± SD Helmut 2016-01-27 13:51
- Geometric means ± SD nobody 2016-01-27 15:20
- Money makes the world go ’round Helmut 2016-01-27 16:11
- Money makes the world go ’round nobody 2016-01-27 16:31
- Fixed or random effect kumarnaidu 2016-11-04 14:05
- PROC GLM fixes Subject mittyri 2016-11-04 23:00
- PROC GLM fixes Subject kumarnaidu 2016-11-05 05:22
- PROC GLM fixes Subject mittyri 2016-11-05 10:13
- PROC GLM fixes Subjectkumarnaidu 2016-11-07 06:24
- PROC GLM fixes Subject mittyri 2016-11-07 11:57
- PROC GLM fixes Subject kumarnaidu 2016-11-07 12:42
- PROC GLM fixes Subject mittyri 2016-11-07 11:57
- PROC GLM fixes Subjectkumarnaidu 2016-11-07 06:24
- PROC GLM fixes Subject mittyri 2016-11-05 10:13
- PROC GLM fixes Subject kumarnaidu 2016-11-05 05:22
- PROC GLM fixes Subject mittyri 2016-11-04 23:00
- Fixed or random effect kumarnaidu 2016-11-04 14:05
- Money makes the world go ’round nobody 2016-01-27 16:31
- Money makes the world go ’round Helmut 2016-01-27 16:11
- Geometric means ± SD Ben 2016-11-08 21:20
- Misunderstanding Helmut 2016-11-09 15:29
- Misunderstanding Ben 2016-11-14 19:40
- RTFM Helmut 2016-11-14 21:50
- Misunderstanding Ben 2016-11-14 19:40
- Misunderstanding Helmut 2016-11-09 15:29
- Geometric means ± SD nobody 2016-01-27 15:20
- FDA 'own' SAS code for 2x2 d_labes 2016-01-27 09:57
- On random effects and bogus statements ElMaestro 2016-01-22 12:13
- R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 01:26
- R code for analyzing classical 2X2 crossover designed bioequivalence data ElMaestro 2016-01-22 00:59