Bioequivalence and Bioavailability Forum • PROC GLM fixes Subject

PROC GLM fixes Subject [🇷 for BE/BA]

posted by kumarnaidu – Mumbai, India, 2016-11-05 06:22 (3522 d 10:08 ago) – Posting: # 16775
Views: 27,563

Hi Mittyri

Thanks for your reply.

❝ Seems to be odd but here Subject is still fixed as ElMaestro wrote. So the experts are right (and ElMaestro too :-D )

Ok that means sub(seq) is a random effect in proc glm. But what about above query from WHO. Also in EMA que and answer guidance they said all effects should be fixed rather than random (method A). Also as you said there is no meaning of random statement in proc glm. EMA Method also dont have such statement. My confusion is that in the protocol can we write that sub, period, sequence, treatment and sub(seq) will be a fixed effects and seq will be tested against sub(seq) if I am going to use Proc glm.

Thanks

—
Kumar Naidu

Complete thread:

R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 00:13 [🇷 for BE/BA]
- R code for analyzing classical 2X2 crossover designed bioequivalence data ElMaestro 2016-01-22 00:59
  - R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 01:26
    - On random effects and bogus statements ElMaestro 2016-01-22 12:13
      - FDA 'own' SAS code for 2x2 d_labes 2016-01-27 09:57
        
        FDA 'own' SAS code for 2x2 nobody 2016-01-27 10:09
        
        OT: PM to ElMaestro Helmut 2016-01-27 13:39
        On coffee and such... ElMaestro 2016-01-27 13:47
      - Geometric means ± SD Helmut 2016-01-27 13:51
        
        Geometric means ± SD nobody 2016-01-27 15:20
        
        Money makes the world go ’round Helmut 2016-01-27 16:11
        
        Money makes the world go ’round nobody 2016-01-27 16:31
        
        Fixed or random effect kumarnaidu 2016-11-04 14:05
        
        PROC GLM fixes Subject mittyri 2016-11-04 23:00
        
        PROC GLM fixes Subjectkumarnaidu 2016-11-05 05:22
        
        PROC GLM fixes Subject mittyri 2016-11-05 10:13
        
        PROC GLM fixes Subject kumarnaidu 2016-11-07 06:24
        
        PROC GLM fixes Subject mittyri 2016-11-07 11:57
        
        PROC GLM fixes Subject kumarnaidu 2016-11-07 12:42
        
        Geometric means ± SD Ben 2016-11-08 21:20
        
        Misunderstanding Helmut 2016-11-09 15:29
        
        Misunderstanding Ben 2016-11-14 19:40
        
        RTFM Helmut 2016-11-14 21:50