Fixed or random effect [🇷 for BE/BA]

posted by kumarnaidu – Mumbai, India, 2016-11-04 15:05 (3163 d 18:33 ago) – Posting: # 16773
Views: 24,361

Hello All,
Recently we got one query from WHO for 2x2 crossover study "Please take into account that if a mixed effect ANOVA model with the main effects of treatment, period and sequence as fixed effect and subjects nested within sequence as random effect is going to be used, as defined in the protocol, in SAS this refers to PROC MIXED as defined in the FDA guidelines. However, the protocol states at the same time that the sequence effect will be tested using the subjects nested within sequence mean square from the ANOVA as the error term. All other main effects will be tested against the residual error (mean square error/MSE) from the ANOVA as the error term. This refers to PROC GLM of SAS. This inconsistency should be corrected."

As per some experts if we want to keep sub(seq) as a error term for testing seq then it should be random rather than fixed.
But as I understand all effects in the PROC GLM are fixed including sub(seq).
Can anybody help me out?

Thanks in advance.

Kumar Naidu

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