Bioequivalence and Bioavailability Forum • Group effects EMA

Group effects EMA [Two-Stage / GS Designs]

posted by VStus – Poland, 2016-10-06 20:06 (1400 d 19:30 ago) – Posting: # 16701
Views: 29,400

Hi Helmut,

I have performed exercise on this dataset in R and have to support Mittyri: addition of more effects beyond group increases MSE and, therefore, CI:




anova(lm(log(response) ~ sequence + subject:sequence + period + treatment, data=data, na.action=na.exclude))["Residuals","Mean Sq"]


[1] 0.00075363

anova(lm(log(response) ~ sequence + subject:sequence + period + treatment + group, data=data, na.action=na.exclude))["Residuals","Mean Sq"]


[1] 0.00075363

anova(lm(log(response) ~ sequence + subject:sequence + period + treatment + group + period:group, data=data, na.action=na.exclude))["Residuals","Mean Sq"]


[1] 0.00078534

Due to my limited R knowledge, I cannot figure out how to add other effects recommended by FDA e.g. subject(sequence x group), but I'm afraid that at least in R, the more related effects - the wider confidence intervals...

Regards, VStus

Complete thread:

Potvin C in the EU Helmut 2013-04-16 17:40
- Potvin C in the EU ElMaestro 2013-04-17 02:31
  - Potvin C in the EU Helmut 2013-04-17 12:23
    - 2 Groups model FDA d_labes 2013-04-17 13:10
      - 2 Groups model FDA Helmut 2013-04-17 16:37
        
        Group effects obsolete? d_labes 2013-04-18 09:55
        
        Group effects FDA/EMA Helmut 2013-04-19 14:34
        
        Group effects FDA/EMA mittyri 2014-08-21 15:34
        
        Group effects FDA/EMA ElMaestro 2014-08-21 17:31
        
        Group effects EMA mittyri 2014-10-01 11:25
        
        Group effects EMA ElMaestro 2014-10-01 11:31
        Group effects EMA Helmut 2014-10-01 13:24
        
        Group effects EMAVStus 2016-10-06 22:06
        
        Group effects EMA ElMaestro 2016-10-07 12:45
        
        Group effects EMA mittyri 2016-10-07 15:06
        
        Fixed effects model with Group term mittyri 2016-10-09 13:27
        
        Fixed effects model: changing the F, p values mittyri 2016-10-10 18:33
        
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        FDA group model in R ElMaestro 2016-10-12 01:07
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        FDA group model in R ElMaestro 2016-10-17 18:58
        
        FDA group model in R VStus 2016-10-20 13:57
        
        Fixed effects model with Group term VStus 2016-10-20 13:54
        
        Group effects FDA/EMA zizou 2016-12-31 02:54
        
        Group effects FDA/EMA Helmut 2017-06-03 14:57
        
        2 Groups model FDA hiren379 2013-08-22 14:32
        
        Homework Helmut 2013-08-23 11:53