Group effects EMA [Two-Stage / GS Designs]

posted by VStus – Poland, 2016-10-06 22:06  – Posting: # 16701
Views: 29,091

Hi Helmut,

I have performed exercise on this dataset in R and have to support Mittyri: addition of more effects beyond group increases MSE and, therefore, CI:

anova(lm(log(response) ~ sequence + subject:sequence + period + treatment, data=data, na.action=na.exclude))["Residuals","Mean Sq"]
[1] 0.00075363
anova(lm(log(response) ~ sequence + subject:sequence + period + treatment + group, data=data, na.action=na.exclude))["Residuals","Mean Sq"]
[1] 0.00075363
anova(lm(log(response) ~ sequence + subject:sequence + period + treatment + group + period:group, data=data, na.action=na.exclude))["Residuals","Mean Sq"]
[1] 0.00078534


Due to my limited R knowledge, I cannot figure out how to add other effects recommended by FDA e.g. subject(sequence x group), but I'm afraid that at least in R, the more related effects - the wider confidence intervals...

Regards, VStus

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