Bioequivalence and Bioavailability Forum • “Gravity Duration”

“Gravity Duration” [PK / PD]

posted by Helmut – Vienna, Austria, 2016-09-26 01:47 (2763 d 01:27 ago) – Posting: # 16677
Views: 16,262

Hi Yung-jin,

❝ Finally, I have a question: when using NCA to analyze a BE dataset, we can obtain MRT. Apparently this MRT is not what we call MRT_po. What is it?

See this post. IIRC, AUMC/AUC for ev administration was sometimes called in the “old days” of PK the Gravity Duration (GD).

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Complete thread:

volume of distribution at steady state martin 2011-10-18 07:49 [PK / PD]
- Vss d_labes 2011-10-18 11:36
  - History Helmut 2011-10-18 16:02
    - History javier 2016-09-21 16:47
      - Amazon? Yes. yjlee168 2016-09-22 11:30
        
        Gold Letters d_labes 2016-09-22 12:09
        
        Gold Letters yjlee168 2016-09-24 20:26
        
        Another quest mittyri 2016-09-25 15:04
        
        TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
        
        TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
        
        TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
        
        TopFit: less than 1.44 MB ElMaestro 2016-09-26 09:43
        
        TopFit: 16bit DOS-application yjlee168 2016-09-26 00:18
- volume of distribution at steady state ElMaestro 2016-09-23 23:13
  - Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
    - it seems possible for me... yjlee168 2016-09-24 20:19
      - Leslie disagrees mittyri 2016-09-24 21:33
        
        OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
        
        MRTINF includes Mean Input Time mittyri 2016-09-25 23:45
        “Gravity Duration”Helmut 2016-09-25 23:47
    - Was Leslie wrong about Eq (8)? yjlee168 2016-09-26 00:13
      - Leslie cannot be wrong mittyri 2016-09-26 00:23