Leslie disagrees [PK / PD]

posted by mittyri  – Russia, 2016-09-24 23:33 (3207 d 10:39 ago) – Posting: # 16672
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Dear Yung-jin,

That's kind of incorrect.

Vss/F = (dosepo x AUMC0-infinity) / AUC20-infinity.

This equation was derived from the original one (please see equation (7) in my previous post) using assumption which is hold only for bolus:
MRT = AUMC0-infinity/AUC0-infinity

❝ Again we can also re-arrange Vss = (F x Dose/AUC0-infinity)x MRT as Vss/F = (Dose/AUC0-infinity)x MRT = Cl x MRT.

That's right, and now please see equation (8) from my previous post.

Kind regards,
Mittyri

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