Bioequivalence and Bioavailability Forum • Leslie disagrees

Leslie disagrees [PK / PD]

posted by mittyri – Russia, 2016-09-24 23:33 (3189 d 00:55 ago) – Posting: # 16672
Views: 18,999

Dear Yung-jin,

That's kind of incorrect.

❝ Vss/F = (dose_po x AUMC_0-infinity) / AUC²_0-infinity.

This equation was derived from the original one (please see equation (7) in my previous post) using assumption which is hold only for bolus:
MRT = AUMC_0-infinity/AUC_0-infinity

❝ Again we can also re-arrange Vss = (F x Dose/AUC_0-infinity)x MRT as Vss/F = (Dose/AUC_0-infinity)x MRT = Cl x MRT.

That's right, and now please see equation (8) from my previous post.

—
Kind regards,
Mittyri

Complete thread:

volume of distribution at steady state martin 2011-10-18 07:49 [PK / PD]
- Vss d_labes 2011-10-18 11:36
  - History Helmut 2011-10-18 16:02
    - History javier 2016-09-21 16:47
      - Amazon? Yes. yjlee168 2016-09-22 11:30
        
        Gold Letters d_labes 2016-09-22 12:09
        
        Gold Letters yjlee168 2016-09-24 20:26
        
        Another quest mittyri 2016-09-25 15:04
        
        TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
        
        TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
        
        TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
        
        TopFit: less than 1.44 MB ElMaestro 2016-09-26 09:43
        
        TopFit: 16bit DOS-application yjlee168 2016-09-26 00:18
- volume of distribution at steady state ElMaestro 2016-09-23 23:13
  - Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
    - it seems possible for me... yjlee168 2016-09-24 20:19
      - Leslie disagreesmittyri 2016-09-24 21:33
        
        OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
        
        MRTINF includes Mean Input Time mittyri 2016-09-25 23:45
        “Gravity Duration” Helmut 2016-09-25 23:47
    - Was Leslie wrong about Eq (8)? yjlee168 2016-09-26 00:13
      - Leslie cannot be wrong mittyri 2016-09-26 00:23