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Registervolume of distribution at steady state [PK / PD]
Hi all,
Isn't the proposal by Martin quite reasonable in its simple logic if an estimate of F is available?
I read the answers to his post, and while I gather there's possibly a sentiment towards "no can do!" the argument seems to be merely "because this book says so" where in actuality the book assumes implicitly that no estimate of F (and through that, MRT) is known.
We don't have to be sheep, right?
❝ How can the volume of distribution at steady state be calculated under this model? Can the above formula be adjusted straightforwardly using the bioavailability F to calculate Vss = (dosepo x F x AUMC0-infinity) / AUC20-infinity?
Isn't the proposal by Martin quite reasonable in its simple logic if an estimate of F is available?
I read the answers to his post, and while I gather there's possibly a sentiment towards "no can do!" the argument seems to be merely "because this book says so" where in actuality the book assumes implicitly that no estimate of F (and through that, MRT) is known.
We don't have to be sheep, right?
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- volume of distribution at steady state martin 2011-10-18 07:49 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Vss d_labes 2011-10-18 11:36
- History Helmut 2011-10-18 16:02
- History javier 2016-09-21 16:47
- Amazon? Yes. yjlee168 2016-09-22 11:30
- Gold Letters d_labes 2016-09-22 12:09
- Gold Letters yjlee168 2016-09-24 20:26
- Another quest mittyri 2016-09-25 15:04
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: less than 1.44 MB ElMaestro 2016-09-26 09:43
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: 16bit DOS-application yjlee168 2016-09-26 00:18
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- Another quest mittyri 2016-09-25 15:04
- Gold Letters yjlee168 2016-09-24 20:26
- Gold Letters d_labes 2016-09-22 12:09
- Amazon? Yes. yjlee168 2016-09-22 11:30
- History javier 2016-09-21 16:47
- History Helmut 2011-10-18 16:02
- volume of distribution at steady stateElMaestro 2016-09-23 23:13
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- it seems possible for me... yjlee168 2016-09-24 20:19
- Leslie disagrees mittyri 2016-09-24 21:33
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- MRTINF includes Mean Input Time mittyri 2016-09-25 23:45
- “Gravity Duration” Helmut 2016-09-25 23:47
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- Leslie disagrees mittyri 2016-09-24 21:33
- Was Leslie wrong about Eq (8)? yjlee168 2016-09-26 00:13
- Leslie cannot be wrong mittyri 2016-09-26 00:23
- it seems possible for me... yjlee168 2016-09-24 20:19
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- Vss d_labes 2011-10-18 11:36
Ing. Helmut Schütz