Bioequivalence and Bioavailability Forum

❝ I don't know the reason of using this metric in the article you're reading.

me neither really, its about pharmacokinetics between a innovator and a generic drugs in a single dose with a drug's infusion of 60 minutes.

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❝ But I would cite a classic one¹

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❝ So you don't need MD data to get Vss. By the way be aware! Only bolus/infusion data are apllicable (see here)

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❝ 1. Gibaldi M, D Perrier D. Pharmacokinetics. New York: Marcel Dekker; 2nd ed. 1982

Thanks you very much for your time, this answer is awesome.

In my opinion, they use this pk parameter because with it they dont need to use a bicompartmental model to analize de data, only the non-compartmental one. (may be for money)

Thanks again!!