Bioequivalence and Bioavailability Forum • Difficulties with NCA BEAR

Difficulties with NCA BEAR [🇷 for BE/BA]

posted by xtianbadillo – Mexico, 2016-09-16 00:44 (3561 d 06:23 ago) – Posting: # 16646
Views: 17,000

Dear yjlee168

I had the same problem, thanks to your contribution, I changed the default settings as you said and the issue was solved.

❝ Do you use the default setting to analyze your data? I think the error is due to failure to find a lambda_z during NCA (invalid 'y' when doing linear regression). If the error still persists, please check your data carefully. Or try to switch lambda_z estimation method to 'Select 2-6 data points manually' (lambda_z estimation = 5) instead of using the default of 'Adjusted R sq. (ARS).' By the way, manual data point selection may also provide you a chance to check subjects' data individually. Hope this can help.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28 [🇷 for BE/BA]
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEARxtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42