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RegisterThe reasons not to pool [Power / Sample Size]
Dear Astea,
your questions seems to me rhetorical
We are pooling not the data sets, but some statistical parameters (pooled CVs), so Simpson's paradox is another story
You cannot be sure till the moment you have the CSR in your hands. Even then, I wouldn't be sure taking into account the quality of data management in some CRO. So the gut feeling weighting is the best.
By the way have you heard about pilot studies in Russia? I'm not
I think it depends on many things (PK linearity, sensitivity of the method).
I suppose you have a huge data base (may be even the best in Russia ), so you can analyze some trends by yourself. In my experience the IntraSCV is usually higher for low strengths (but not for all cases)
your questions seems to me rhetorical
❝ As I understand, pooling CV is a part of metha-analysis. In its turn meta-analysis conceals many suprises, Simpson's paradox as example.
We are pooling not the data sets, but some statistical parameters (pooled CVs), so Simpson's paradox is another story
❝ The question is how to make sure of homogenity of pooling data? What can be the reasons to throw out some outlier data, excluding Gut feeling?
You cannot be sure till the moment you have the CSR in your hands. Even then, I wouldn't be sure taking into account the quality of data management in some CRO. So the gut feeling weighting is the best.
By the way have you heard about pilot studies in Russia? I'm not
❝ Can we pool data from studies with different dosage or studies with different formulations? How do the strength of the dosage affects variability?
I think it depends on many things (PK linearity, sensitivity of the method).
I suppose you have a huge data base (may be even the best in Russia
), so you can analyze some trends by yourself. In my experience the IntraSCV is usually higher for low strengths (but not for all cases)—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Why do we need pooled CV? BE-proff 2016-08-24 08:48 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Maximum CV might be misleading Helmut 2016-08-24 12:07
- Maximum CV might be misleading BE-proff 2016-08-26 10:41
- Pooling – example Helmut 2016-08-26 11:34
- Pooling – example BE-proff 2016-12-28 14:37
- in my protocols… Helmut 2016-12-29 12:27
- Pooling – example BE-proff 2016-12-28 14:37
- Pooling – example Helmut 2016-08-26 11:34
- Maximum CV might be misleading BE-proff 2016-08-26 10:41
- Why do we need pooled CV? ElMaestro 2016-08-24 13:03
- Yessir! Common sense! Helmut 2016-08-24 13:53
- Common sense weighting before pooling mittyri 2016-08-24 15:13
- Gut feeling is the answer! DavidManteigas 2016-08-25 11:09
- The reasons not to pool Astea 2016-08-26 20:40
- The reasons not to poolmittyri 2016-08-28 22:05
- Know your drug/formulation! Helmut 2016-08-29 11:56
- The reasons not to pool Astea 2016-08-26 20:40
- Yessir! Common sense! Helmut 2016-08-24 13:53
- Maximum CV might be misleading Helmut 2016-08-24 12:07
Ing. Helmut Schütz