Bioequivalence and Bioavailability Forum • The reasons not to pool

The reasons not to pool [Power / Sample Size]

posted by Astea – Russia, 2016-08-26 22:40 (2971 d 12:06 ago) – Posting: # 16597
Views: 11,938

Dear all!

As I understand, pooling CV is a part of metha-analysis. In its turn meta-analysis conceals many suprises, Simpson's paradox as example. The question is how to make sure of homogenity of pooling data? What can be the reasons to throw out some outlier data, excluding Gut feeling? Can we pool data from studies with different dosage or studies with different formulations? How do the strength of the dosage affects variability?

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

Why do we need pooled CV? BE-proff 2016-08-24 08:48 [Power / Sample Size]
- Maximum CV might be misleading Helmut 2016-08-24 12:07
  - Maximum CV might be misleading BE-proff 2016-08-26 10:41
    - Pooling – example Helmut 2016-08-26 11:34
      - Pooling – example BE-proff 2016-12-28 14:37
        
        in my protocols… Helmut 2016-12-29 12:27
- Why do we need pooled CV? ElMaestro 2016-08-24 13:03
  - Yessir! Common sense! Helmut 2016-08-24 13:53
    - Common sense weighting before pooling mittyri 2016-08-24 15:13
  - Gut feeling is the answer! DavidManteigas 2016-08-25 11:09
    - The reasons not to poolAstea 2016-08-26 20:40
      - The reasons not to pool mittyri 2016-08-28 22:05
      - Know your drug/formulation! Helmut 2016-08-29 11:56