Bioequivalence and Bioavailability Forum

Site and Treatment as fixed. [General Statistics]

posted by ElMaestro – Denmark, 2016-06-10 09:17 (3307 d 16:38 ago) – Posting: # 16426
Views: 6,933

Hi Dr Ripal,

❝ To be precise it is single dose two way cross over study of one of the taxanes and I am looking for the literature which supports evaluation of site effect and/or disease effect in bioequivalence studies.

Well, then it is a crossover and you need at least Site, Treatment, Sequence, Period, Subject in the model. Ideally Site has a high p-value.

❝ I have not come across literature of any patient based bioequivalence study which evaluates site effect as variable in statistical analysis.

Try harder. Google is your friend.

—
Pass or fail!
ElMaestro

Complete thread:

how to evaluate site/center effect in multicentric bioequivalence study? Dr Ripal 2016-06-09 14:08 [General Statistics]
- how to evaluate site/center effect in multicentric bioequivalence study? BE-proff 2016-06-09 15:03
- See some previous topics mittyri 2016-06-09 15:21
- Site and Treatment as fixed. ElMaestro 2016-06-09 19:39
  - Site and Treatment as fixed. Dr Ripal 2016-06-10 05:57
    - Site and Treatment as fixed.ElMaestro 2016-06-10 07:17
- how to evaluate site/center effect in multicentric bioequivalence study? DavidManteigas 2016-06-15 18:30

Site and Treatment as fixed. [General Sta­tis­tics]

Complete thread:

Site and Treatment as fixed. [General Statistics]