Bioequivalence and Bioavailability Forum • Linear Pharmacokinetics of Levamlodipine

Linear Pharmacokinetics of Levamlodipine [PK / PD]

posted by Mauricio Sampaio – Brazil, 2016-06-10 00:03 (3202 d 17:14 ago) – Posting: # 16423
Views: 8,256

Dear Martin

❝ Please note that there is hardly no way to show or proof linear PK in clinical studies.

You told.."In clinical studies!" Question: is there any other way to proof linear PK or your text mean...PK linear is a theoric concept? like linear coefficient (r2) = 0,9999999

❝ You usually assess dose-proportionality which is a consequence of linear PK (i.e. linear PK implies dose-proportionality but not necessarily vice versa).

How many is accepted dose-proportional? 5%, 10%, 15% between diferent strengths?

Complete thread:

Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2015-10-07 00:24 [PK / PD]
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-03 22:33
  - Quantification of S-amlodipine Mauricio Sampaio 2016-06-06 16:19
    - Quantification of S-amlodipine Helmut 2016-06-06 20:23
      - Quantification of S-amlodipine nobody 2016-06-07 08:29
        
        Quantification of S-amlodipine Mauricio Sampaio 2016-06-07 18:35
        
        Quantification of S-amlodipine Helmut 2016-06-08 01:32
        
        Quantification of S-amlodipine Mauricio Sampaio 2016-06-09 21:48
- Linear Pharmacokinetics of Levamlodipine martin 2016-06-09 15:22
  - Linear Pharmacokinetics of LevamlodipineMauricio Sampaio 2016-06-09 22:03
    - Linear Pharmacokinetics of Levamlodipine martin 2016-06-12 21:48