Quantification of S-amlodipine [PK / PD]

posted by Mauricio Sampaio  – Brazil, 2016-06-06 18:19 (3167 d 16:02 ago) – Posting: # 16402
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Dear,

Amlodipine is a racemic mixture of [-]S and [+]R-enantiomeric forms, with the S-amlodipine, also known as Levamlodipine, having analgesic activity.
Considering the main objective in bioanalysis will be development an achiral method, simple, sensitive, rapid and reliable mass spectrometry for the quantification of S-amlodipine in human plasma. I ask you,...can I use Amlodipine (racemic) instead of S-amlodipine (enantiomeric form) as analitical standard?

Note: The volunteers just will administrate Levamlodipine.

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