Bioequivalence and Bioavailability Forum

Compilation [Study Assessment]

posted by Helmut – Vienna, Austria, 2016-05-24 16:27 (2561 d 03:16 ago) – Posting: # 16359
Views: 28,243

Dear all,

in R / lmerTest() one can get maximum likelihood estimation by setting the argument REML=FALSE in the model statement (default is REML=TRUE). Satterthwaite’s DF are 10.858 for the intercept and 6.884 for the slope. In lme() use method="ML" (default is method="REML"). Below a compilation (in analogy to BE rounded to four decimal figures and grouped by “similarity”):

Software        Method      Estimate      90% CI   

═══════════════════════════════════════════════════

SAS (Smith)   ML/Satter.   B₀ 1.94    1.54   2.35  

                           B₁ 0.7615  0.679  0.844 

SAS           ML/Satter.   B₀ 1.9425  1.5391 2.3458

                           B₁ 0.7615  0.6789 0.8441

R lmerTest    ML/Satter.   B₀ 1.9425  1.5391 2.3458

                           B₁ 0.7615  0.6789 0.8441

───────────────────────────────────────────────────

R lme         ML           B₀ 1.9425  1.5175 2.3675

                           B₁ 0.7615  0.6738 0.8491

───────────────────────────────────────────────────

SAS           ML/contain.  B₀ 1.9414  1.5175 2.3675

                           B₁ 0.7615  0.6738 0.8491

───────────────────────────────────────────────────

SAS           REML/Satter. B₀ 1.9414  1.4968 2.3860

                           B₁ 0.7617  0.6696 0.8539

PHX/WNL       REML/Satter. B₀ 1.9414  1.4968 2.3860

                           B₁ 0.7617  0.6696 0.8539

R lmerTest    REML/Satter. B₀ 1.9414  1.4968 2.3860

                           B₁ 0.7617  0.6696 0.8539

───────────────────────────────────────────────────

NCSS          method?      B₀ 1.9414  1.4849 2.3978

                           B₁ 0.7617  0.6659 0.8576

───────────────────────────────────────────────────

SAS           ML/contain.  B₀ 1.9414  1.4807 2.4020

                           B₁ 0.7617  0.6665 0.8570

R lme         REML         B₀ 1.9414  1.4807 2.4020

                           B₁ 0.7617  0.6665 0.8570

───────────────────────────────────────────────────

PHX/WNL       REML/resid.  B₀ 1.9414  1.4515 2.4313

                           B₁ 0.7617  0.6665 0.8570

My preference is REML/Satterthwaite because one could reproduce results in three different software packages. I would avoid NCSS; no idea how the calculation is done.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Science Quotes

Complete thread:

Dose Proportionality and Variance AngusMcLean 2016-05-11 16:55 [Study Assessment]
- More information, please Helmut 2016-05-12 14:34
  - More information, please AngusMcLean 2016-05-13 16:40
    - Setup in Phoenix/WinNonlin Helmut 2016-05-14 02:26
      - Setup in Phoenix/WinNonlin AngusMcLean 2016-05-14 18:54
        
        Setup in Phoenix/WinNonlin Helmut 2016-05-15 14:47
        
        Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 15:17
        
        Phoenix 64 Warning Helmut 2016-05-15 15:56
        
        Phoenix 64 Warning AngusMcLean 2016-05-15 20:11
        
        OT: imperial vs. metric units Helmut 2016-05-16 16:26
        
        Setup in Phoenix/WinNonlin ElMaestro 2016-05-15 20:54
        
        Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 22:30
      - Setup in Phoenix/WinNonlin AngusMcLean 2016-05-16 21:00
        
        NCSS vs. PHX/WNL vs. SAS Helmut 2016-05-17 01:50
        
        NCSS vs. PHX/WNL vs. SAS - Validation? mittyri 2016-05-18 08:23
        
        Diagnostics ElMaestro 2016-05-18 09:20
        
        Diagnostics: R and Phoenix Helmut 2016-05-18 15:14
        
        Diagnostics: R zizou 2016-05-22 19:07
        
        Diagnostics: R Helmut 2016-05-23 01:22
        
        SASian potpourri d_labes 2016-05-24 12:02
        
        CompilationHelmut 2016-05-24 14:27
        
        REML or not d_labes 2016-05-24 16:33
        
        complete or not Helmut 2016-05-24 16:57
        
        Compilation AngusMcLean 2016-05-26 16:46
        
        doubts about NCSS Helmut 2016-05-26 19:13
        
        Doubts about NCSS zizou 2016-05-26 23:38
        
        Compilation AngusMcLean 2016-05-28 00:51
        
        Kenward-Roger? Helmut 2016-05-28 15:59
        
        90% confidence interval for R_dnm Shuanghe 2019-01-04 17:45
        
        90% confidence interval for R_dnm d_labes 2019-01-05 14:01
        
        Visualizing lmer and limits mittyri 2019-01-06 17:00
        
        Visualizing lmer and limits Shuanghe 2019-01-07 11:05
        Visualizing lmer and limits d_labes 2019-01-07 15:08
        
        Visualizing lmer and limits mittyri 2019-01-13 23:53
        
        90% confidence interval for R_dnm Shuanghe 2019-01-07 10:53
        
        90% confidence interval for R_dnm d_labes 2019-01-07 15:17
        
        90% confidence interval for R_dnm Shuanghe 2019-01-07 17:11
        
        90% confidence interval for R_dnm d_labes 2019-01-07 18:24
        offtop: greek letters and tables mittyri 2019-01-08 00:19
        
        OT: greek letters and symbols Helmut 2019-02-02 16:04
        
        Smith’s paper Helmut 2016-05-18 14:44
        
        Smith’s paper d_labes 2019-01-05 15:00

Compilation [Study As­sess­ment]

Complete thread:

Compilation [Study Assessment]