PPI Washout [Design Issues]

posted by jag009  – NJ, 2016-05-16 00:19 (3198 d 16:32 ago) – Posting: # 16311
Views: 4,375

❝ Dear Jay,


❝ ❝ The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable?


❝ This is elimination half life we are talking about not the half life of drug action. ;-)


You are using mean? Better look at the SD and ranges.

John

Complete thread:

UA Flag
Activity
 Admin contact
23,381 posts in 4,914 threads, 1,663 registered users;
45 visitors (0 registered, 45 guests [including 9 identified bots]).
Forum time: 15:52 CET (Europe/Vienna)

Science is built up with facts, as a house is with stones.
But a collection of facts is no more a science
than a heap of stones is a house.    Henri Poincaré

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5