Bioequivalence and Bioavailability Forum

Phoenix 64 Warning [Study As­sess­ment]

posted by Helmut  – Vienna, Austria, 2016-05-15 17:56 (2895 d 13:21 ago) – Posting: # 16307
Views: 30,954

Hi Angus,

❝ I am having difficulty with Phoenix: I get an error message when the program loads relating to a missing framework. It tells me that the program may not work properly.

I’m getting this message for a few months as well (only in the 64-bit version of Phoenix):

Environment: Windows 7 Pro SP1 (64bit) build 7601, Phoenix 64 build 6.4.0.768, .NET Framework 4.6.1 (last security update 2016-05-11).
Since I didn’t change my Phoenix-installation I suspect Billy-boy causing the trouble… I guess one of these February/March security updates are the reason: KB3122661, KB3127233, KB3136000.

❝ I was able to get an evaluation for residual error for both Cmax and AUC0-t. The values were indeed very similar to what I had obtained in PHoenix (e.g. Cmax CV(%) was 19.9 compared with 20.06 (BE result). The CV(%) for AUC0-t ws 12.2 compared with 12.6% by BE approach).

Congratulations!

❝ Other worker has reported CV(%) of 0.1 for AUC0-t. I am wondering if using SAS you can get a result of 0.1. For Cmax other worker reports CV% 10.1. I do not think using SAS can give such a difference?

Never seen that. We cross-validated Phoenix/WinNonlin and SAS many times. I think that he/she screwed up completely. I love “push-the-button” statisticians reporting a 0.1% CV (‼) without hesitation. How plausible is that? Good morning!
Body height can be measured pretty precisely. Ask the worker whether he/she thinks that repeated measurements can be done to ±1/16″. If the answer is yes, ask which variability he/she expects in AUC.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Dose Proportionality and Variance AngusMcLean 2016-05-11 16:55 
  • More information, please Helmut 2016-05-12 14:34
    • More information, please AngusMcLean 2016-05-13 16:40
      • Setup in Phoenix/WinNonlin Helmut 2016-05-14 02:26
        • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-14 18:54
          • Setup in Phoenix/WinNonlin Helmut 2016-05-15 14:47
            • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 15:17
              • Phoenix 64 WarningHelmut 2016-05-15 15:56
                • Phoenix 64 Warning AngusMcLean 2016-05-15 20:11
                  • OT: imperial vs. metric units Helmut 2016-05-16 16:26
              • Setup in Phoenix/WinNonlin ElMaestro 2016-05-15 20:54
                • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 22:30
        • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-16 21:00
          • NCSS vs. PHX/WNL vs. SAS Helmut 2016-05-17 01:50
            • NCSS vs. PHX/WNL vs. SAS - Validation? mittyri 2016-05-18 08:23
              • Diagnostics ElMaestro 2016-05-18 09:20
                • Diagnostics: R and Phoenix Helmut 2016-05-18 15:14
                  • Diagnostics: R zizou 2016-05-22 19:07
                    • Diagnostics: R Helmut 2016-05-23 01:22
                      • SASian potpourri d_labes 2016-05-24 12:02
                        • Compilation Helmut 2016-05-24 14:27
                          • REML or not d_labes 2016-05-24 16:33
                            • complete or not Helmut 2016-05-24 16:57
                          • Compilation AngusMcLean 2016-05-26 16:46
                            • doubts about NCSS Helmut 2016-05-26 19:13
                              • Doubts about NCSS zizou 2016-05-26 23:38
                          • Compilation AngusMcLean 2016-05-28 00:51
                            • Kenward-Roger? Helmut 2016-05-28 15:59
                          • 90% confidence interval for R_dnm Shuanghe 2019-01-04 17:45
                            • 90% confidence interval for R_dnm d_labes 2019-01-05 14:01
                              • Visualizing lmer and limits mittyri 2019-01-06 17:00
                                • Visualizing lmer and limits Shuanghe 2019-01-07 11:05
                                • Visualizing lmer and limits d_labes 2019-01-07 15:08
                                  • Visualizing lmer and limits mittyri 2019-01-13 23:53
                              • 90% confidence interval for R_dnm Shuanghe 2019-01-07 10:53
                                • 90% confidence interval for R_dnm d_labes 2019-01-07 15:17
                                  • 90% confidence interval for R_dnm Shuanghe 2019-01-07 17:11
                                    • 90% confidence interval for R_dnm d_labes 2019-01-07 18:24
                                    • offtop: greek letters and tables mittyri 2019-01-08 00:19
                                      • OT: greek letters and symbols Helmut 2019-02-02 16:04
              • Smith’s paper Helmut 2016-05-18 14:44
                • Smith’s paper d_labes 2019-01-05 15:00