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RegisterPPI Washout [Design Issues]
Dear All,
The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable? As PPI influence the acid level by inhibiting the acid release from parietal cells, so would this effect the absorption of the drug if washout is kept 1-2 days.
Regards,
Jay
Edit: Category changed; see also this post #1. [Helmut]
The halflife of Proton pump inhibitors is around 2 hrs, so 10 half life sums up to 20 hrs. So for BE Study considering the washout as 1-2 days would be acceptable? As PPI influence the acid level by inhibiting the acid release from parietal cells, so would this effect the absorption of the drug if washout is kept 1-2 days.
Regards,
Jay
Edit: Category changed; see also this post #1. [Helmut]
Complete thread:
- PPI WashoutJay 2016-05-11 08:57 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- PPI Washout luvblooms 2016-05-11 12:06
- PPI Washout jag009 2016-05-15 22:19
- PPI Washout luvblooms 2016-05-11 12:06
Ing. Helmut Schütz