Bioequivalence and Bioavailability Forum • Alpha inflation ?

Alpha inflation ? [Design Issues]

posted by Ohlbe – France, 2016-05-03 17:48 (3347 d 10:22 ago) – Posting: # 16271
Views: 8,395

Dear all,

❝ If you want to apply the EMA’s ABEL, a mixed-effects model is not acceptable. If you want to apply the FDA’s RSABE [...]

Any idea about alpha inflation control with such a design ?

—
Regards
Ohlbe

Complete thread:

Sas proc mixed and 4 period partial replicate Cross over M.tareq 2016-05-03 11:35 [Design Issues]
- What is the purpose? Helmut 2016-05-03 12:43
  - What is the purpose? M.tareq 2016-05-03 15:06
  - Alpha inflation ?Ohlbe 2016-05-03 15:48
    - Alpha inflation d_labes 2016-05-03 16:06
    - Not with such a high CV Helmut 2016-05-03 17:49
      - High CV? d_labes 2016-05-03 21:07
        
        Acc. to WHO PQTm Helmut 2016-05-03 21:58
        
        Sofosbuvir d_labes 2016-05-04 11:50

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