Sas proc mixed and 4 period partial replicate Cross over [Design Issues]

posted by M.tareq  – 2016-05-03 11:35 (2215 d 06:40 ago) – Posting: # 16266
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Hello, can any one please guide me on performing stat analysis of a 4 period 4 seq 3 treatment partial replicate Cross over study, where the ref product only replicate against t1 and t2 for a bioequivlence study of sofosbuvir?
The FDA recommendation is for full replicate and there are little information found regarding a 4 period Cross over with partial replication?
What other effects to account for beside the usual fixed effects in traditional 2x2 Cross over?
Within subject effect, within formulation variability, and carry over effect?
Thanks in advance

Newbie in stat...

Edit: Category changed; see also this post #1. [Helmut]

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