Which Tmax to be consider in case of b.i.d. dosing? [NCA / SHAM]
Dear Helmut,
Thanks for your valuable information. I understood that all PK-metrics of both dosing interval should be provided but if i wish to conclude the result, Which Cmax i should consider?
❝ Essentially it boils down to the target you had in mind developing the MR formulation. I would explore all PK-metrics in both intervals (pAUC0–τ, Cmax,0–τ, tmax,0–τ and pAUCτ–t, Cmax,τ–t, tmax,τ–t) as well as the global ones (AUC0–t, Cmax, tmax).
Thanks for your valuable information. I understood that all PK-metrics of both dosing interval should be provided but if i wish to conclude the result, Which Cmax i should consider?
Complete thread:
- Which Tmax to be consider in case of b.i.d. dosing? maulik963 2016-04-13 08:06 [NCA / SHAM]
- Which Tmax to be consider in case of b.i.d. dosing? BE-proff 2016-04-13 09:27
- Which Tmax to be consider in case of b.i.d. dosing? maulik963 2016-04-13 13:09
- Which Tmax to be consider in case of b.i.d. dosing? Helmut 2016-04-13 13:49
- Which Tmax to be consider in case of b.i.d. dosing?maulik963 2016-04-16 12:32
- Which Tmax to be consider in case of b.i.d. dosing? Helmut 2016-04-13 13:49
- Which Tmax to be consider in case of b.i.d. dosing? maulik963 2016-04-13 13:09
- Which Tmax to be consider in case of b.i.d. dosing? BE-proff 2016-04-13 09:27