comparative bioavailability [General Statistics]
Hi Helmut,
Can you please suggest when to use TOST (two one sided t-tests) for comparative bio availability in stead of a standard ANOVA approach using period, treatment, subjects as random effects? I was reading through
https://sphhp.buffalo.edu/content/dam/sphhp/biostatistics/Documents/techreports/UB-Biostatistics-TR1107.pdf
And also-
two one-sided tests” (TOST) proposed by Schuirmann (1987)
http://www.ncss.com/wp-content/themes/ncss/pdf/Procedures/PASS/Equivalence_Tests_for_Two_Means_using_Differences.pdf
Can you please suggest when to use TOST (two one sided t-tests) for comparative bio availability in stead of a standard ANOVA approach using period, treatment, subjects as random effects? I was reading through
https://sphhp.buffalo.edu/content/dam/sphhp/biostatistics/Documents/techreports/UB-Biostatistics-TR1107.pdf
And also-
two one-sided tests” (TOST) proposed by Schuirmann (1987)
http://www.ncss.com/wp-content/themes/ncss/pdf/Procedures/PASS/Equivalence_Tests_for_Two_Means_using_Differences.pdf
—
Dr. Hiren Mehta
Dr. Hiren Mehta
Complete thread:
- comparative bioavailabilityhirenpharm 2016-04-15 19:41 [General Statistics]
- 100(1–2α) CI Helmut 2016-04-18 14:02
- 100(1–2α) CI hirenpharm 2016-04-21 16:28
- 100(1–2α) CI Helmut 2016-04-18 14:02