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RegisterMissing data analyses [Regulatives / Guidelines]
Dear all!
Recently I've received a letter from the Customer where it was pointed out that according to the planning regulatory documents we have to include missing data in analyses in a very specific way. For example in several cases the missing data from one volunteer in one period should be replaced be the mean arithmetic of the other's data.
Of course this method has a right to exist. It was described in European Pharmacopeia 5.0 p.3.2.6 and in several articles, but it seems to me very strange to use this technic in bioequivalence data analyses.
Looking forward for your points of view!
Recently I've received a letter from the Customer where it was pointed out that according to the planning regulatory documents we have to include missing data in analyses in a very specific way. For example in several cases the missing data from one volunteer in one period should be replaced be the mean arithmetic of the other's data.
Of course this method has a right to exist. It was described in European Pharmacopeia 5.0 p.3.2.6 and in several articles, but it seems to me very strange to use this technic in bioequivalence data analyses.
Looking forward for your points of view!
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Missing data analysesAstea 2016-04-11 10:33 [Regulatives / Guidelines]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Data imputation Helmut 2016-04-11 13:13
- Data imputation Astea 2016-04-11 17:53
- Missing data analyses Hutchy_7 2016-04-12 13:38
- Missing sample(s) Helmut 2016-04-12 14:06
- Missing sample(s) Hutchy_7 2016-04-12 15:29
- Missing sample(s) Helmut 2016-04-12 14:06
- Data imputation Helmut 2016-04-11 13:13
Ing. Helmut Schütz