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AUC0-tau at steady state [NCA / SHAM]

posted by BNR - US, 2016-03-31 22:46  - Posting: # 16159
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I have a question about AUC0-tau calculation when using actual sampling time. For example, the dosing interval is 24 hr and the 24-hr sample was drawn at 23.8hr. If lambda is not able to be obtained (eg. the concentration-time profile is flat during dosing interval), Phoenix 6.4 will not calculate the AUC0-tau value as extrapolation is not possible. What is the best way to hand this case, reporting a missing value for AUC0-tau or replacing 23.8hr with 24hr for the calculation? Thanks for your help in advance!

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