Significant ≠ relevant [Design Issues]

posted by ElMaestro  – Denmark, 2016-03-25 00:12 (3242 d 07:44 ago) – Posting: # 16138
Views: 24,242

Hi Astea,

❝ I think that including term to ANOVA to prove it's significance is a bit naive because the true reasons may be various ("We shall see what we shall see"). What is your opinion on that topic?


Correct. Not much likely to be significant anyway, but it can certainly be done. You do probably not run substantial risk by doing so just do it if they ask for it.

❝ And some practical questions:

❝ 1. Which ANOVA model should be preffered in that cases Group, Group x Sequence or... ?(would be very grateful for link)?


Group x Sequence?? Why not just group, tested against the between subject MS?

❝ 2. As I understand the residual variance depends on the quantity of terms (and even the more number of terms the less residual). Can we perform 2 different ANOVA models: first to exclude group effect, and second - to make a standard treatm+period+seq+sub(seq) calcaulation?


Not totally sure, but group would be a between-factor, so I think the residual (and its df) will be the same with and without Group.

❝ 3. What if we do get significant group term? Can we somehow make sure that number of subjects from only one group is sufficient for the study? What else can we take in such a case?


Well, in my opinion that would not change much. You still include both groups in the calculation.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,376 posts in 4,912 threads, 1,667 registered users;
147 visitors (0 registered, 147 guests [including 6 identified bots]).
Forum time: 07:56 CET (Europe/Vienna)

The great tragedy of Science – the slaying
of a beautiful hypothesis by an ugly fact.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5