Training required [Bioanalytics]
Hi Mohamed,
… who apparently has not completed his training yet. SCNR.
I fully agree with Ohlbe. In assessing (in)accuracy/(im)precision of bioanalytical methods we are only interested in back-calculated concentrations. Haven’t seen anything else in 30+ years.
Since you wanted a reference, see how the EMA’s BMV-GL defines the LLOQ:
(Back calculated) concentrations. Period.
❝ I am writing from Egypt […] this apparently came from a new member who joined the BE Evaluation committee.
… who apparently has not completed his training yet. SCNR.

❝ I welcome other comments from members.
I fully agree with Ohlbe. In assessing (in)accuracy/(im)precision of bioanalytical methods we are only interested in back-calculated concentrations. Haven’t seen anything else in 30+ years.
Since you wanted a reference, see how the EMA’s BMV-GL defines the LLOQ:
The lower limit of quantification (LLOQ) is the lowest concentration of analyte in a sample which can be quantified reliably, with an acceptable accuracy and precision.
See also what the GL says about the calibration curve and accuracy.(Back calculated) concentrations. Period.
—
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:
- Precision in bioanalytical assays Mohamed Rashed 2016-03-17 08:46 [Bioanalytics]
- Precision in bioanalytical assays Ohlbe 2016-03-17 10:13
- Precision in bioanalytical assays Mohamed Rashed 2016-03-17 14:13
- Training requiredHelmut 2016-03-17 16:18
- Precision in bioanalytical assays Mohamed Rashed 2016-03-17 14:13
- Precision in bioanalytical assays Ohlbe 2016-03-17 10:13