0.00 concentration value between two measurable concentrations [NCA / SHAM]

posted by arl_stat – India, 2016-03-02 11:13 (3267 d 08:28 ago) – Posting: # 16042
Views: 6,381

Hello Forum Members,

In a data, we received 0.00 concentration value between two measurable concentrations. How to handle this?
Should we exclude the 0.00 concentration value for calculation of AUC?
Also what is the regulatory requirements.

For eg:
Subj  Conc
1     0.00
1     0.00
1     0.00
1     0.00
1     0.36
1     0.00
1     0.00
1     0.00
1     0.71
1    25.79
1    99.09
1    85.30
1    66.10
1    35.62
1    12.61
1     0.00
1     0.00
1     4.69
1     3.83
1     3.12
1     2.21
1     1.81
1     1.11
1     0.73
1     0.00
1     0.25
1     0.00
1     0.00
1     0.00


Thanks.


Edit: Category changed. Can you please post sampling times instead of the subject number? [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,379 posts in 4,913 threads, 1,661 registered users;
258 visitors (0 registered, 258 guests [including 17 identified bots]).
Forum time: 19:42 CET (Europe/Vienna)

Science is what you know.
Philosophy is what you don’t know.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5