Bioequivalence and Bioavailability Forum

Baseline; another example [Regulatives / Guidelines]

posted by nobody – 2016-02-12 10:10 (3260 d 04:24 ago) – Posting: # 15980
Views: 19,772

Dear Mr. Helmut!

Thanks, very nice indeed! Can we start a diploma thesis with adding some more random effects on the baseline (physiology jumps around like hell in practice, due to health status, sports, sleep, food etc.). Would love to see a large set of simulations taking into account all that!

Some 20 years ago I set up some S-plus simulations "retro-NONMEM" with true values and all kinds of variability to study the potential influence of analytical variability on BE decisions. Unfortunately never finished (end of academic time ) and lost the files while moving over from one computer to the next in the pre-NAS era...

Complete thread:

• Baseline correction vs non-baseline cor­rection jag009 2015-09-15 20:29 [Regulatives / Guidelines] 
  • Baseline correction vs non-baseline correction Lucas 2015-09-16 14:16
    • Baseline correction vs non-baseline correction Relaxation 2015-09-18 10:25
  • Baseline correction or supra-thera­peu­tic dose Helmut 2015-09-16 15:16
    • Baseline correction or supra-thera­peu­tic dose Ohlbe 2015-09-16 17:55
      • Baseline profile prior to each period? Helmut 2015-09-16 18:15
      • Baseline correction examples Helmut 2015-09-17 15:44
        • Baseline correction examples Lucas 2015-09-18 14:19
          • Baseline correction examples Helmut 2015-09-18 17:28
            • Baseline correction examples Mauricio Sampaio 2016-02-07 03:05
              • Baseline correction examples Lucas 2016-02-10 11:48
                • Postmenopausal women Helmut 2016-02-10 12:26
                • Baseline correction examples Mauricio Sampaio 2016-02-11 01:38
                • Baseline correction examples Dr_Dan 2016-02-11 09:22
                  • Postmenopausal women Mauricio Sampaio 2016-02-12 03:24
                    • Postmenopausal women Dr_Dan 2016-02-15 17:45
            • Baseline correction examples BEQool 2024-11-11 07:34
              • Baseline correction GeoMean and Median mittyri 2024-11-11 11:20
                • Geometric mean? Helmut 2024-11-11 14:53
                  • Geometric mean? BEQool 2024-11-14 08:19
                    • Geometric mean ≈ MLE of median Helmut 2024-11-14 09:54
                      • Geometric mean ≈ MLE of median Mahmoud 2024-11-15 11:26
                        • Bias? Helmut 2024-11-16 08:43
                          • Bias? Mahmoud 2024-11-16 11:12
      • Baseline; another example Helmut 2015-09-18 17:16
        • Baseline; another examplenobody 2016-02-12 09:10
          • Baseline; another example Helmut 2016-02-12 13:37
            • Baseline; another example nobody 2016-02-12 14:08
              • Slowly going OT: BE study simulations Helmut 2016-02-12 15:47
                • Slowly going OT: BE study simulations nobody 2016-02-12 16:15
                  • Religious debate Helmut 2016-02-12 17:04
                    • Religious debate nobody 2016-02-12 17:26
                      • Religious debate ElMaestro 2016-02-13 12:53
                        • Religious debate nobody 2016-02-14 15:23
                • Slowly going OT: BE study simulations Ohlbe 2016-02-13 13:10
                  • Slowly going OT: BE study simulations Helmut 2016-02-13 15:02
                    • Slowly going OT: BE study simulations lizhao 2016-02-25 17:31
                      • Business as usual Helmut 2016-02-25 17:44
                        • Business as usual lizhao 2016-02-25 17:59