random effect, fix effect in the guidance Appendix E [Regulatives / Guidelines]

posted by d_labes  – Berlin, Germany, 2008-02-07 11:14 (5866 d 12:22 ago) – Posting: # 1597
Views: 14,197

Hello LS,

nearly correct i think.

Random effect is subject.

The rest of Proc MIXED code in the RANDOM statement is the specification that this random effect is bivariate normal distributed with mean=0 and variance-covariance matrix
|s2T     covTR|
|covTR   s2R  |

i.e. has different variabilities for test and reference as you see, and a covariance term to account for the fact that observations at the same subject are correlated.
The type= option defines the variance-covariance matrix and its parametrization.

But again see my reference cited above for a deeper insight.

Regards,

Detlew

Complete thread:

UA Flag
Activity
 Admin contact
22,916 posts in 4,807 threads, 1,646 registered users;
42 visitors (0 registered, 42 guests [including 11 identified bots]).
Forum time: 23:37 CET (Europe/Vienna)

Nothing shocks me. I’m a scientist.    Harrison Ford (as Indiana Jones)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5