Bioequivalence and Bioavailability Forum • random effect, fix effect in the guidance Appendix E

random effect, fix effect in the guidance Appendix E [Regulatives / Guidelines]

posted by d_labes – Berlin, Germany, 2008-02-07 11:14 (6265 d 12:24 ago) – Posting: # 1597
Views: 15,393

Hello LS,

nearly correct i think.

Random effect is subject.

The rest of Proc MIXED code in the RANDOM statement is the specification that this random effect is bivariate normal distributed with mean=0 and variance-covariance matrix

|s²_T     cov_TR|

|cov_TR   s²_R  |

i.e. has different variabilities for test and reference as you see, and a covariance term to account for the fact that observations at the same subject are correlated.
The type= option defines the variance-covariance matrix and its parametrization.

But again see my reference cited above for a deeper insight.

—
Regards,

Detlew

Complete thread:

random effect, fix effect in the guidance Appendix E LS 2008-02-05 18:53 [Regulatives / Guidelines]
- random effect, fix effect in the guidance Appendix E d_labes 2008-02-06 13:34
  - random effect, fix effect in the guidance Appendix E LS 2008-02-06 17:58
    - random effect, fix effect in the guidance Appendix Ed_labes 2008-02-07 10:14
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