Garbage [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2016-02-10 09:34 (3292 d 19:04 ago) – Posting: # 15967
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Dear Lara,

❝ Someswara Roa. K et al. "Sample Size Estimation for Highly variable drugs using reference scaled average bioequivalence criteria". International Journal of Recent Scientific Research Vol. 6 Issue 7, pp.5040-5045, July, 2015.


forget this "gem" of science literature. It's simply crap. Don't believe even in comma of this paper. Throw it in a high arc into your waste bin.

Use instead:
Laszlo Tothfalusi and Laszlo Endrenyi
"Sample Sizes for Designing Bioequivalence Studies for Highly Variable Drugs"
J Pharm Pharmaceut Sci (www.cspsCanada.org) 15(1) 73 - 84, 2011
Online here.

The described simulation approach to get power/sample size is implemented in the R-package PowerTOST.

Regards,

Detlew

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